Unemployment Rate in Cherokee County, OK was 3.60% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Cherokee County, OK reached a record high of 9.70 in January of 1991 and a record low of 2.20 in April of 2023. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Cherokee County, OK - last updated from the United States Federal Reserve on April of 2026.