Unemployment Rate in Missouri was 4.40% in March of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Missouri reached a record high of 12.30 in April of 2020 and a record low of 2.00 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Missouri - last updated from the United States Federal Reserve on April of 2026.