Resident Population in Knoxville, TN (MSA) was 968.13700 Thous. of Persons in January of 2025, according to the United States Federal Reserve. Historically, Resident Population in Knoxville, TN (MSA) reached a record high of 968.13700 in January of 2025 and a record low of 617.57300 in January of 2000. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Knoxville, TN (MSA) - last updated from the United States Federal Reserve on May of 2026.