Unemployment Rate in Midwest Census Region was 4.10% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Midwest Census Region reached a record high of 15.40 in April of 2020 and a record low of 3.30 in March of 2023. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Midwest Census Region - last updated from the United States Federal Reserve on March of 2026.