Unemployment Rate in Franklin County, MO was 3.00% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Franklin County, MO reached a record high of 13.10 in February of 2010 and a record low of 1.80 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Franklin County, MO - last updated from the United States Federal Reserve on March of 2026.