Resident Population in St. Charles County, MO was 423.72600 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in St. Charles County, MO reached a record high of 423.72600 in January of 2024 and a record low of 92.95400 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in St. Charles County, MO - last updated from the United States Federal Reserve on April of 2026.