Resident Population in South Carolina was 5570.27400 Thous. of Persons in January of 2025, according to the United States Federal Reserve. Historically, Resident Population in South Carolina reached a record high of 5570.27400 in January of 2025 and a record low of 1342.00000 in January of 1900. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in South Carolina - last updated from the United States Federal Reserve on March of 2026.