Resident Population in South Carolina was 5478.83100 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in South Carolina reached a record high of 5478.83100 in January of 2024 and a record low of 1342.00000 in January of 1900. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in South Carolina - last updated from the United States Federal Reserve on February of 2026.