Resident Population in Pickens County, SC was 138.20700 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Pickens County, SC reached a record high of 138.20700 in January of 2024 and a record low of 58.95600 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Pickens County, SC - last updated from the United States Federal Reserve on April of 2026.