Unemployment Rate in Jefferson City, MO (MSA) was 2.50% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Jefferson City, MO (MSA) reached a record high of 8.30 in January of 2010 and a record low of 1.30 in October of 1999. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Jefferson City, MO (MSA) - last updated from the United States Federal Reserve on April of 2026.