Unemployment Rate in Clayton County, IA was 4.50% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Clayton County, IA reached a record high of 11.30 in April of 2020 and a record low of 1.90 in September of 2018. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Clayton County, IA - last updated from the United States Federal Reserve on April of 2026.