Resident Population in Cherokee County, SC was 57.77000 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Cherokee County, SC reached a record high of 57.77000 in January of 2024 and a record low of 36.66900 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Cherokee County, SC - last updated from the United States Federal Reserve on April of 2026.