Unemployment Rate in Port St. Lucie, FL (MSA) was 4.90% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Port St. Lucie, FL (MSA) reached a record high of 15.30 in June of 1992 and a record low of 3.10 in August of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Port St. Lucie, FL (MSA) - last updated from the United States Federal Reserve on April of 2026.