Unemployment Rate in Monroe County, MO was 3.30% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Monroe County, MO reached a record high of 14.90 in February of 2010 and a record low of 2.00 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Monroe County, MO - last updated from the United States Federal Reserve on April of 2026.