De Soto County, FL - Unemployment Rate in DeSoto County, FL was 5.60% in December of 2025, according to the United States Federal Reserve. Historically, De Soto County, FL - Unemployment Rate in DeSoto County, FL reached a record high of 14.00 in July of 2010 and a record low of 2.60 in April of 2006. Trading Economics provides the current actual value, an historical data chart and related indicators for De Soto County, FL - Unemployment Rate in DeSoto County, FL - last updated from the United States Federal Reserve on April of 2026.