Unemployment Rate in Cherokee County, SC was 6.40% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Cherokee County, SC reached a record high of 16.90 in January of 2010 and a record low of 2.10 in September of 2019. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Cherokee County, SC - last updated from the United States Federal Reserve on April of 2026.