Unemployment Rate in Cape Girardeau County, MO was 2.80% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Cape Girardeau County, MO reached a record high of 10.20 in April of 2020 and a record low of 1.80 in April of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Cape Girardeau County, MO - last updated from the United States Federal Reserve on April of 2026.