Unemployment Rate in Cape Girardeau County, MO was 3.80% in March of 2026, according to the United States Federal Reserve. Historically, Unemployment Rate in Cape Girardeau County, MO reached a record high of 10.20 in April of 2020 and a record low of 1.80 in April of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Cape Girardeau County, MO - last updated from the United States Federal Reserve on June of 2026.