Unemployment Rate in Boone County, MO was 2.60% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Boone County, MO reached a record high of 7.40 in April of 2020 and a record low of 0.70 in October of 1999. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Boone County, MO - last updated from the United States Federal Reserve on April of 2026.