Resident Population in Macoupin County, IL was 43.89500 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Macoupin County, IL reached a record high of 49.90200 in January of 1981 and a record low of 43.89500 in January of 2024. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Macoupin County, IL - last updated from the United States Federal Reserve on March of 2026.