Resident Population in Florence-Muscle Shoals, AL (MSA) was 156.60900 Thous. of Persons in January of 2025, according to the United States Federal Reserve. Historically, Resident Population in Florence-Muscle Shoals, AL (MSA) reached a record high of 156.60900 in January of 2025 and a record low of 141.26300 in January of 2003. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Florence-Muscle Shoals, AL (MSA) - last updated from the United States Federal Reserve on May of 2026.