Resident Population in Cape Girardeau County, MO was 83.65800 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Cape Girardeau County, MO reached a record high of 83.65800 in January of 2024 and a record low of 49.35000 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Cape Girardeau County, MO - last updated from the United States Federal Reserve on April of 2026.