Unemployment Rate in St. Lucie County, FL was 5.10% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in St. Lucie County, FL reached a record high of 21.40 in July of 1992 and a record low of 2.90 in December of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in St. Lucie County, FL - last updated from the United States Federal Reserve on April of 2026.