Resident Population in Knox County, IL was 48.71600 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Knox County, IL reached a record high of 62.30000 in January of 1975 and a record low of 48.66300 in January of 2023. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Knox County, IL - last updated from the United States Federal Reserve on April of 2026.