Unemployment Rate in Knox County, IL was 5.80% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Knox County, IL reached a record high of 14.70 in April of 2020 and a record low of 2.70 in May of 1998. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Knox County, IL - last updated from the United States Federal Reserve on April of 2026.