St. Louis, MO-IL - Resident Population in St Louis, MO-IL (MSA) was 2811.92700 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, St. Louis, MO-IL - Resident Population in St Louis, MO-IL (MSA) reached a record high of 2828.99000 in January of 2009 and a record low of 2493.00000 in January of 1977. Trading Economics provides the current actual value, an historical data chart and related indicators for St. Louis, MO-IL - Resident Population in St Louis, MO-IL (MSA) - last updated from the United States Federal Reserve on April of 2026.