Resident Population in St. Clair County, IL was 251.14900 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in St. Clair County, IL reached a record high of 285.59100 in January of 1970 and a record low of 251.14900 in January of 2024. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in St. Clair County, IL - last updated from the United States Federal Reserve on April of 2026.