Resident Population in Lancaster, PA (MSA) was 563.29300 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Lancaster, PA (MSA) reached a record high of 563.29300 in January of 2024 and a record low of 471.81800 in January of 2000. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Lancaster, PA (MSA) - last updated from the United States Federal Reserve on April of 2026.