Resident Population in De Soto County, MS was 195.87100 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in De Soto County, MS reached a record high of 195.87100 in January of 2024 and a record low of 35.88500 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in De Soto County, MS - last updated from the United States Federal Reserve on April of 2026.