Unemployment Rate in St. Louis City, MO was 3.70% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in St. Louis City, MO reached a record high of 12.90 in May of 2020 and a record low of 2.30 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in St. Louis City, MO - last updated from the United States Federal Reserve on April of 2026.