Unemployment Rate in Andrew County, MO was 2.70% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Andrew County, MO reached a record high of 9.40 in January of 2010 and a record low of 1.70 in April of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Andrew County, MO - last updated from the United States Federal Reserve on April of 2026.