Unemployment Rate in San Luis Obispo County, CA was 4.30% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in San Luis Obispo County, CA reached a record high of 15.50 in April of 2020 and a record low of 2.50 in May of 2019. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in San Luis Obispo County, CA - last updated from the United States Federal Reserve on April of 2026.