Unemployment Rate in Knoxville, TN (MSA) was 3.20% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Knoxville, TN (MSA) reached a record high of 13.70 in April of 2020 and a record low of 2.90 in December of 2021. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Knoxville, TN (MSA) - last updated from the United States Federal Reserve on April of 2026.