Unemployment Rate in Gainesville, FL (MSA) was 5.30% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Gainesville, FL (MSA) reached a record high of 9.30 in July of 2010 and a record low of 2.20 in December of 1998. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Gainesville, FL (MSA) - last updated from the United States Federal Reserve on February of 2026.