Unemployment Rate in Florence, SC (MSA) was 5.30% in December of 2025, according to the United States Federal Reserve. Historically, Unemployment Rate in Florence, SC (MSA) reached a record high of 12.80 in January of 2010 and a record low of 2.20 in September of 2019. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Florence, SC (MSA) - last updated from the United States Federal Reserve on April of 2026.