Total Gross Domestic Product for Knoxville, TN (MSA) was 64382.64900 Mil. of $ in January of 2023, according to the United States Federal Reserve. Historically, Total Gross Domestic Product for Knoxville, TN (MSA) reached a record high of 64382.64900 in January of 2023 and a record low of 23115.12300 in January of 2001. Trading Economics provides the current actual value, an historical data chart and related indicators for Total Gross Domestic Product for Knoxville, TN (MSA) - last updated from the United States Federal Reserve on April of 2026.