Resident Population in Cape Girardeau, MO-IL (MSA) was 98.86200 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in Cape Girardeau, MO-IL (MSA) reached a record high of 98.86200 in January of 2024 and a record low of 90.42900 in January of 2000. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Cape Girardeau, MO-IL (MSA) - last updated from the United States Federal Reserve on April of 2026.