Frankfurt's DAX 40 closed about 1.1% down at 25,372 on Thursday, pulling back from one-month highs, tracking other European peers.
Rising oil prices, geopolitical tensions, concerns over AI infrastructure spending, and uncertainty in France weighed on investor sentiment.
Meanwhile, the earnings season continued.
Technology, industrial, and banking sectors led the declines, while software and telecom stocks outperformed.
German companies benefiting from AI, such as Infineon, Hochtief, Siemens Energy Siemens plunged between 3.9%-7.6%.
Other top losers included MTU Aero Engines (-4.3%), Commerzbank (-4.1%), Deutsche Bank (-2.6%), RWE (-2.2%) and Airbus (-2.2%).
On the upside, shares of Qiagen NV (+4.9%) stood out, after Swedish investor EQT agreed to acquire the diagnostics firm in a deal valuing it at €10.8 billion, including debt.
Software giant SAP gained 3.2%, after posting record quarterly revenue, driven by the cloud segment, prompting the company to raise its full-year outlook.